The Week 4 fantasy football running back tier list starts with an important PSA from the creator, who recorded this on Thursday evening before heading to a weekend wedding. Key injuries could change rankings, and updates will be posted in the pinned comment.

Will They Play? (Injury Concerns):

Joe Mixon (Houston Texans) is unlikely to play due to missing practices.
Dameon Pierce also hasn’t practiced, making Cam Akers a possible fill-in.
Kenneth Walker (Seahawks) may return for Monday Night Football but has a tough matchup.
Raheem Mostert is expected back in a limited role.
Austin Ekeler is ruled out.
Jaylen Warren might sit this week, boosting Najee Harris.
Bucky Irving (hamstring) is questionable.

Locked-in RB1s (Top 12):

Players who are must-starts include:

Devon Achane
Aaron Jones
James Conner
Saquon Barkley
Breece Hall

Jonathan Taylor

They all have favorable matchups, while some have bad ones like Alvin Kamara and Bijan Robinson.

High-End RB2s (RB13-RB18):

Brian Robinson (RB13) benefits from a high-scoring game environment.
Travis Etienne (RB14) has a good matchup against the Texans.
Derrick Henry (RB15) faces a Ravens defense that could allow him to shine if Tennessee stays ahead.

Josh Jacobs (RB16) faces the Packers’ strong defense.
David Montgomery (RB17) continues to outperform expectations.
Zack Moss (RB18) has dominated snaps and should continue to thrive against a weaker defense.

Low-End RB2s (RB19 and Below):

Rachaad White could rise in rankings if his teammate, Bucky Irving, sits.
Devin Singletary is set to face a struggling Cowboys run defense, giving him a favorable outlook.